diff --git a/src/portable/synopsys/dwc2/dwc2_stm32.h b/src/portable/synopsys/dwc2/dwc2_stm32.h
index 9da8de41f..516eb021b 100644
--- a/src/portable/synopsys/dwc2/dwc2_stm32.h
+++ b/src/portable/synopsys/dwc2/dwc2_stm32.h
@@ -337,6 +337,9 @@ TU_ATTR_ALWAYS_INLINE static inline uint32_t round_up_to_cache_line_size(uint32_
 }
 
 TU_ATTR_ALWAYS_INLINE static inline bool is_cache_mem(uintptr_t addr) {
+  if (0 == (SCB->CCR & SCB_CCR_DC_Msk)) {
+    return false; // D-Cache is disabled
+  }
   for (unsigned int i = 0; i < TU_ARRAY_SIZE(uncached_regions); i++) {
     if (uncached_regions[i].start <= addr && addr <= uncached_regions[i].end) { return false; }
   }